Stiff Person's syndrome

Specialty: Neurology

Recommendations:

IVIG is an option for treatment of Stiff Person syndrome if GABAergic medications fail or for patients who have contraindications to GABAergic medications.

Dose:

Initial dose:

Adults: Total dose of 2 g/kg divided over 2 to 5 days.

Pediatric: Total dose of 2 g/kg divided over 2 days.

Maintenance dose: A systematic approach should be taken to determine the minimum effective dose, and continued use of IVIG should be based on objective measures of its sustained effectiveness. Maximum dose of IVIG per treatment course should be 2 g/kg.