Primary Immune Deficiency (PID) Secondary Immune Deficiency (SID)

Specialty: Immunology


IVIG is recommended in hypogammaglobulinemia (total IgG reduced or inadequate antibody production) with recurrent bacterial infections. 

Children and adults with a suspected immunodeficiency should be referred to an immunologist with expertise in the field of primary immunodeficiency ('expert' in PID). Ideally, this should be carried out in an academic centre with the capability of performing specialized diagnostic tests for immunodeficiency. Management should be performed by a specialized team including physicians, nurses and allied health care providers.


Adult: 0.4-0.6 g/kg/every 3-4 weeks 

Pediatric: 0.3-0.6 g/kg every 3-4 weeks

Does or frequency to be adjusted by experts according to desired trough level (more than 500 mg/dL and ideally 700 mg/dL) and according to individual patient clinical needs.